Clark Kent/Superman - Brandon Routh
For whatever faults Superman Returns had (and I liked it personally) Brandon Routh wasn’t one of them. He’s gone on to prove himself as an actor since (see “Chuck” and Scott Pilgrim vs. the World) and has shown he can pull off that key “powerful, but affable/approachable” vibe effortlessly - just like Superman. With a new script and direction that’s more concerned with building its own world than paying respect to Superman: The Movie, I believe he’d knock it out of the park. Give Routh the cape again - he deserves it.
Lois Lane - Rashida Jones
I almost went with Zooey Deschanel here (who would be a fine choice as well) but then Jones came to mind and struck me as a natural fit - and I think she could better pull off that assertive, take-no-crap attitude that Lois needs. She can do smart, fearless, and looks good in a suit - combine the three and you have the perfect 21st century Lois Lane.
Lex Luthor - Billy Zane
Brainiac - Joseph Gordon LevittInception - incidentally directed by new Superman producer Christopher Nolan. Play up the cold-and-calculating, and he'd do great as the corrupted Kryptonian artificial intelligence - possibly created by Superman's birth father, Jor-El. Brainiac is one of Superman's more famous villains, yet has never been used in a feature film before. And using the robotic Brainiac would give him a villain he could hit, which is kind of a plus.
Perry White - John Goodman
Jimmy Olsen - Johnny SimmonsScott Pilgrim vs. The World, and fully captured the part of the bright-eyed fan waiting for his turn in the spotlight. That's basically the "before" picture of Planet photographer Jimmy Olsen, who becomes Superman's pal and goes on crazy adventures all the time. All Simmons needs is a bottle of hair dye.
Jonathan and Martha Kent - Jeff Bridges and Patricia Clarkson
Jor-El and Lara - Jon Hamm and Elizabeth Mitchellclaims he’s too old to be Superman. I don’t necessarily agree - if they’re focusing on a long-established version of the character, he’d be the ideal choice. However, if they’re trying to build a franchise and want to skew a bit younger for the first installment, then he’s certainly age-appropriate to place the infant Kal-El in a rocket to Earth and help guide him from beyond the grave via holographic messages in the Fortress. And while it’s not a huge part, I think he’d really sell the part of a conflicted scientist coping with the loss of his world and forced into making an uneasy choice in order to save his child.
Mitchell pulled off being cold and alien as well as warm and loving brilliantly on “Lost”. Like with Jor-El, the Lara role wouldn't be huge, but I think she would add a lot as Superman’s mother on Krypton. Even better, follow the lead of the comic miniseries "Superman: Birthright" and have Lara be Jor-El’s partner not only in marriage but also in Kryptonian science, giving Mitchell some more to work with than previous versions of the character.
Cat Grant - Jane Krakowski
Ron Troupe - Phil LaMarr
Steve Lombard - Nathan FillionThe sports writer for the Planet, Steve Lombard is an insufferable, obnoxious, egotistical jackass. He's the kind of guy who'll insult your manhood while tying to pick up your girlfriend right in front of you. And I don't know of anyone who can play that kind of role as hilariously as Nathan Fillion (just see Dr. Horrible's Sing-Along Blog).